A study of Anemia and its association with COPD, in patients attending tertiary care hospital.

  • Abhijeet Khandelwal DTCD DNB FCCP, Consultant Pulmonologist, Greater Kailash Hospital,11/A, Old Palasia Indore (MP) 452018- India
  • Sandeep Tilve DTCD DNB FCCP, Consultant Pulmonologist, Greater Kailash Hospital,11/A, Old Palasia Indore (MP) 452018- India
  • Fatima Mamnoon DNB, FCCP, Consultant Pulmonologist, Lilavati Hospital & Research Centre,A-791, Bandra Reclamation, Bandra (W) Mumbai - 400 050, India
  • Prahlad P. Prabhudesai DNB, FCCP, Consultant Pulmonologist, Lilavati Hospital & Research Centre,A-791, Bandra Reclamation, Bandra (W) Mumbai - 400 050, India
Keywords: Anemia, COPD, FEV1, MMRC


Chronic obstructive pulmonary disease COPD, a common preventable and treatable disease which recognized as global public health problem. COPD is expected to become the third leading cause of death worldwide by 2020[8]. COPD patients with low haemoglobin levels have a poorer prognosis than COPD patients with normal haemoglobin levels.


[ 1 ] Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2011 Available from: Global Initiative for Chronic Obstructive lung Disease (GOLD), Web site: http://www.goldcopd.org/uploads/users/files/GOLDReport_April112011.pdf

[ 2 ] P.J. Barnes, B.R. Celli. Systemic manifestations and comorbidities of COPD. European Respiratory Journal 2009.;33(5).

[ 3 ] T.similowski, A. Agustı, W. Macnee. The potential impact of anaemia of chronic disease in COPD. European Respiratory Journal. 2004;27(2)

[ 4 ] Karina Portillo Carroza. Anemia in COPD: Should It Be Taken Into Consideration? Arch Bronconeumol .2007

[ 5 ] Zielinski J. Effects of long-term oxygen therapy in patients with chronic obstructive pulmonary disease. Curr Opin Pulm Med 1999; 5: 81–87.

[ 6 ] John M, Hoernig S, Doehner W, Okonko DD, Witt C, Anker SD. Anemia and inflammation in COPD. Chest 2005; 127: 825–829.

[ 7 ] Chambellan A, Chailleux E, Similowski T, ANTADIR Observatory Group. Prognostic value of hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 2005; 128: 1201–1208.

[ 8 ] K.R. Chapmanet al. Epidemiology and costs of Chronic Obstructive Pulmonary Disease. Eur Respir J 2006; 27: 188–207..

[ 9 ] C. Cote, M.D. Zilberberg, S.H. Mody : Haemoglobin level and its clinical impact ina cohort of patients with COPD. Eur Respir J 2007 ;29

[ 10 ] Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011–1023.

[ 11 ] Means RT Jr. Recent developments in the anemia of chronic disease. Curr Hematol Rep 2003; 2: 116–121.

[ 12 ] Means RT Jr. Advances in the anemia of chronic disease. Int J Hematol 1999; 70: 7–12.

[ 13 ] Moldawer LL, Marano MA, Wei H, et al. Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo. FASEB J 1989; 3: 1637–1643.

[ 14 ] Vander Meer P, Voors AA, Lipsic E, van Gilst WH, van Veldhuisen DJ. Erythropoietin in cardiovascular diseases. Eur Heart J 2004; 25: 285–291.

[ 15 ] Rice L, Alfrey CP, Driscoll T, Whitley CE, Hachey DL, Suki W. Neocytolysis contributes to the anemia of renal disease. Am J Kidney Dis 1999; 33: 59–62.

[ 16 ] Rogers J, Lacroix L, Durmowitz G, Kasschau K, Andriotakis J, Bridges KR. The role of cytokines in the regulation of ferritin expression. Adv Exp Med Biol 1994; 356: 127–132.

[ 17 ] Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructivepulmonary disease and systemic infl ammation: a systematic review and a metaanalysis.Thorax. 2004;59:574-80.

[ 18 ] Portillo K, Belda J, Antón P, Casan P. High frequency of anemia in COPD patients admitted in a tertiary hospital. Rev Clin Esp. 2007; 207:383-7.

[ 19 ] Portillo K. Anemia in COPD: should it be taken into consideration?.Arch Bronconeumol. 2007;43:392-8.

[ 20 ] Tsantes AE, Tassiopoulos ST, Papadhimitriou SI, Bonovas S, Poulakis N, Vlachou A, et al. Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production. Eur J Clin Pharmacol. 2003;59:379-83.

[ 21 ] Harrison's Principles of Internal Medicine. 17th Edition (2008). Pg. 2432 (Table 351-2)

[ 22 ] Krishnan G, Grant BJ, Muti PC, et al. Association between anemia and quality of life in a population sample of individuals with chronic obstructive pulmonary disease. BMC Pulm Med 2006;6:23

[ 23 ] Martínez FJ, Foster G, Curtis JL, Criner G, Weinmann G, Fishman A, et al; NETT Research Group. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med. 2006;173:1326-34.

[ 24 ] Shorr AF, Doyle J, Stern L, Dolgitser M, Zilberberg MD. Anemia in chronic obstructive pulmonary disease: epidemiology and economic implications. Curr Med Res Opin 2008;24(4):1123-1130.

[ 25 ] Roshanak Hasheminasab Zavarreh, Mohammad-mehdi Zahmatkesh. Association between Anemia and COPD in Iranian population, International Journal of Hematology Oncology and Stem Cell Research. 2013;7(2)

[ 26 ] Guralnik JM, Ersshler WB, Schrier SL, Picozzi VJ. Anemia in the elderly: a public health crisis in hematology. Hematology Am Soc Hematol Educ Program 2005; 1: 528–532.

[ 27 ] MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2:50-60.

[ 28 ] Matthias John, Soeren Hoernig. Anemia and Inflammation in COPD, CHEST 2005;127(3).

[ 29 ] Jeffrey A Richmond, Joseph E. Kiss. Anemia in COPD : The role of blood transfusion. Transfusion Medicine Update.2008 : 4.
Original Article