Melatonin-Supported Extracorporeal Shock Wave Treatment Offers an Additional Benefit on Protection against Cyclophosphamide-Induced Acute Interstitial Cystitis in Rat

  • Hsin-Ju Chiang Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
  • Chia-Lo Chang Division of Colorectal Surgery and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
  • Yen-Ta Chen Division of Urology and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
  • Cheuk-Kwan Sun Department of Emergency Medicine, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan
  • Hon-Kan Yip Division of Cardiology and Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Keywords: Acute interstitial cystitis, Melatonin, Extracorporeal shock wave, Cyclophosphamide, Inflammation, Oxidative stress


This study tests the hypothesis that melatonin-assisted extracorporeal shock wave (ECSW) treatment offers an additional protection against cyclophosphamide (CYP 150 mg/kg)-induced acute interstitial cystitis (AIC) in rats. Male Sprague-Dawley rats were treated as sham controls, AIC alone, AIC-melatonin (20 mg/kg at 30 min after CYP and 50 mg/kg at 6h and 18h after CYP), AIC-ECSW, and AIC-melatonin-ECSW (200 impulses at 0.11 mJ/mm2 at 3h and 24h after CYP).


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Original Article